Low-Magnitude Mechanical Loading Becomes Osteogenic When Rest Is Inserted Between Each Load Cycle
نویسندگان
چکیده
منابع مشابه
Low magnitude mechanical loading is osteogenic in children with disabling conditions.
UNLABELLED The osteogenic potential of short durations of low-level mechanical stimuli was examined in children with disabling conditions. The mean change in tibia vTBMD was +6.3% in the intervention group compared with -11.9% in the control group. This pilot randomized controlled trial provides preliminary evidence that low-level mechanical stimuli represent a noninvasive, non-pharmacological ...
متن کاملRest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles.
We hypothesized that a 10-s rest interval (at zero load) inserted between each load cycle would increase the osteogenic effects of mechanical loading near previously identified thresholds for strain magnitude and cycle numbers. We tested our hypothesis by subjecting the right tibiae of female C57BL/6J mice (16 wk, n = 70) to exogenous mechanical loading within a peri-threshold physiological ran...
متن کاملEnabling bone formation in the aged skeleton via rest-inserted mechanical loading.
The mild and moderate physical activity most successfully implemented in the elderly has proven ineffective in augmenting bone mass. We have recently reported that inserting 10 s of unloaded rest between load cycles transformed low-magnitude loading into a potent osteogenic regimen for both adolescent and adult animals. Here, we extended our observations and hypothesized that inserting rest bet...
متن کاملLow magnitude and high frequency mechanical loading prevents decreased bone formation responses of 2T3 preosteoblasts.
Bone loss due to osteoporosis or disuse such as in paraplegia or microgravity is a significant health problem. As a treatment for osteoporosis, brief exposure of intact animals or humans to low magnitude and high frequency (LMHF) mechanical loading has been shown to normalize and prevent bone loss. However, the underlying molecular changes and the target cells by which LMHF mechanical loading a...
متن کاملBone-loading response varies with strain magnitude and cycle number.
Mechanical loading stimulates bone formation and regulates bone size, shape, and strength. It is recognized that strain magnitude, strain rate, and frequency are variables that explain bone stimulation. Early loading studies have shown that a low number (36) of cycles/day (cyc) induced maximal bone formation when strains were high (2,000 microepsilon) (Rubin CT and Lanyon LE. J Bone Joint Surg ...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2002
ISSN: 0884-0431
DOI: 10.1359/jbmr.2002.17.9.1613